United States, November 25, 2025 -- The United States is facing a critical health crisis: more than 42.4% of adults and nearly 20% of adolescents are classified as obese, according to the Centers for Disease Control and Prevention (CDC, 2023). That equates to over 138 million Americans living with obesity-related conditions such as type 2 diabetes, hypertension, coronary heart disease, fattyliver disease, and certain cancers. These conditions collectively contribute to over 300,000 preventable deaths and an estimated $173 billion in annual medical costs each year (CDC, 2023).

Globally, the World Health Organization (WHO, 2023) reports that the number of adults living with obesity has tripled since 1975, reaching more than 890 million people worldwide. Despite the explosion of diets, prescription injections, and short-term detox plans, long-term results remain elusive because most methods target calories rather than underlying hormonal pathways.

One hormone in particular — GLP-1 (Glucagon-Like Peptide-1) — plays a vital role in regulating appetite, satiety, insulin sensitivity, and energy balance. When GLP-1 signaling is impaired, hunger cues intensify, fat storage increases, and sustainable weight loss becomes significantly more difficult.

This is where Sensoriy GLP-1, an advanced, scientifically formulated supplement manufactured in an FDA-registered, cGMP-certified U.S. facility, distinguishes itself. The formula supports natural GLP-1 pathways using clinically researched botanical ingredients, offering a safe, stimulant-free, and sustainable alternative to synthetic injections.

A Science-Driven Approach to Restoring Metabolic Balance

Sensoriy GLP-1 combines five of the most thoroughly studied natural compounds — Berberine, Opuntia ficus-indica, Turmeric Extract, Glucomannan, and Mangosteen Extract — each selected for its clinically validated impact on metabolic health, gut hormones, and long-term weight management.

1. Berberine — A Natural Metabolic Regulator

Berberine is a plant-based alkaloid long used in Eastern medicine and now backed by extensive modern research.

• It activates AMP-activated protein kinase (AMPK), the cellular “master switch” for energy regulation, supporting healthy glucose uptake, lipid metabolism, and mitochondrial efficiency.
• Research also shows that Berberine stimulates GLP-1 secretion by modulating gut microbiota and supporting intestinal L-cells responsible for hormone production.

A 2023 study by Araj-Khodaei et al. found that Berberine increased GLP-1 release and improved insulin sensitivity in intestinal cells by reshaping the microbiome (PubMed 37921026).

Similarly, a 2018 publication in Nutrients & Diabetes demonstrated that Berberine restored GLP-1 expression in obese mice by protecting enterocytes from oxidative stress.

Meta-analyses across more than 40 clinical trials have shown reductions in body weight, triglycerides, and fasting glucose — without the harsh gastrointestinal side effects associated with some injectable GLP-1 drugs.

2. Opuntia ficus-indica — A Desert Botanical That Supports Satiety

Also known as Prickly Pear Cactus, Opuntia ficus-indica has been valued for centuries for its metabolic and anti-inflammatory properties. Its soluble-fiber content slows digestion, stabilizes post-meal blood sugar, and contributes to healthy GLP-1 release through stimulation of enteroendocrine L-cells.

• A 2020 systematic review (Phytotherapy Research) found that Opuntia supplementation reduced LDL cholesterol and total body-fat percentage while improving triglyceride levels.
• In 2025, Arias-Rico et al. reported in Life Journal that Opuntia ficus-indica peel powder improved metabolic markers and protected against obesity by reducing lipid accumulation and modulating oxidative stress.

When combined with Berberine, Opuntia ficus-indica provides a powerful dual mechanism: Berberine activates metabolism, while Opuntia supports feelings of fullness and stabilizes glucose for hormone-balanced weight management.

3. Turmeric Extract (Curcumin)

Curcumin, the primary bioactive compound in Turmeric, is well established for its effects on inflammation-driven metabolic dysfunction.

A 2023 meta-analysis in the American Journal of Clinical Nutrition covering 21 randomized trials found that Curcumin supplementation reduced BMI, waist circumference, and triglycerides, indicating positive effects on insulin resistance and metabolic inflammation.

4. Glucomannan — A Natural Satiety Fiber

Glucomannan, derived from the Konjac root, expands in the stomach to support prolonged fullness and slow nutrient absorption.

A 2020 systematic review in Nutrition Journal concluded that Glucomannan intake significantly reduced body weight, total cholesterol, and LDL-C, particularly when paired with balanced nutrition and physical activity.

5. Mangosteen Extract (Garcinia mangostana)

Mangosteen’s active polyphenols, known as xanthones, provide potent antioxidant and antiinflammatory benefits.

A 2018 clinical trial published in Journal of Nutritional Metabolism found that Mangosteen extract improved insulin sensitivity and reduced waist circumference in obese participants over a 26-week period.

The Sensoriy GLP-1 Advantage

• Supports natural GLP-1 production linked to appetite regulation and satiety
• Enhances metabolic efficiency and insulin sensitivity
• Promotes steady energy levels without caffeine or stimulants
• Helps reduce body-fat percentage and waist circumference
• Manufactured in an FDA-registered, cGMP-certified U.S. facility for purity and potency

Safety and Quality Assurance

Each batch of Sensoriy GLP-1 undergoes third-party laboratory testing for purity, potency, and microbial safety. The formula contains no synthetic hormones, laxatives, or artificial additives, making it suitable for ongoing, long-term use.

Availability

Sensoriy GLP-1 is available globally through the official website and select authorized distributors. Launch pricing and independent laboratory reports can be accessed at www.sensoriy.com.

References

1. CDC. “Adult Obesity Facts.” Centers for Disease Control and Prevention, 2023.
2. WHO. “Obesity and Overweight.” World Health Organization, 2023.
3. Sun Y et al., Nutrients & Diabetes, 2018 — Berberine effects on GLP-1 expression in obese mice.
4. Araj-Khodaei M et al., 2023 — Berberine-induced GLP-1 secretion via microbiota modulation. Frontiers in Endocrinology.
5. Onakpoya IJ et al., 2020 — Phytotherapy Research — Effects of Opuntia ficus-indica on body composition.
6. Arias-Rico J et al., 2025 — Life Journal — Metabolic benefits of Opuntia ficus-indica peel powder.
7. Unhapipatpong C et al., 2023 — American Journal of Clinical Nutrition — Curcumin supplementation meta-analysis.
8. Mohammadpour S et al., 2020 — Nutrition Journal — Effects of Glucomannan on weight and lipids.
9. Watanabe M et al., 2018 — Journal of Nutritional Metabolism — Mangosteen extract and insulin resistance

Contact Info:
Name: Lindsay Pacheco
Email: Send Email
Organization: Sensoriy Health
Website: http://www.sensoriy.com/

Release ID: 89176717

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