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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13D
                    UNDER THE SECURITIES EXCHANGE ACT OF 1934


                         (AMENDMENT NO. _____________)*


                              NEOPROBE CORPORATION
--------------------------------------------------------------------------------
                                (Name of Issuer)


                     COMMON STOCK, PAR VALUE $.001 PER SHARE
--------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                    640518106
--------------------------------------------------------------------------------
                                 (CUSIP Number)

                                  DAVID GERBER
   GREAT POINT PARTNERS, LLC, 2 PICKWICK PLAZA, SUITE 450, GREENWICH, CT 06830
                          TELEPHONE NUMBER 203-971-3300
--------------------------------------------------------------------------------
           (Name, Address and Telephone Number of Person Authorized to
                       Receive Notices and Communications)


                                DECEMBER 14, 2004
--------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule because of ss.ss.240.13d-1(e),  240.13d-1(f) or 240.13d-1(g), check the
following box. ?

NOTE:  Schedule  filed in paper format shall include a signed  original and five
copies of the  schedule,  including  all exhibits.  See  ss.240.13d-7  for other
parties to whom copies are to be sent.

         *The  remainder  of this cover page shall be filled out for a reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

         The information  required in the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise  subject to the  liabilities of that section of
the Act but shall be subject to all other  provisions of the Act  (however,  see
the Notes).




-------------------------
CUSIP No.
-------------------------




                                                                                                 
=========== ==========================================================================================================

    1       NAMES OF REPORTING PERSONS
            Biomedical Value Fund, L.P.
            I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON (ENTITIES ONLY):

            [            ]
----------- ----------------------------------------------------------------------------------------------------------

    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                                                       (a)  [ ]
                                                                                                       (b)  [ ]
----------- ----------------------------------------------------------------------------------------------------------

    3       SEC USE ONLY
----------- ----------------------------------------------------------------------------------------------------------

    4       Source of Funds (See Instructions)  PF
----------- ----------------------------------------------------------------------------------------------------------

    5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e)
----------- ----------------------------------------------------------------------------------------------------------

    6       CITIZENSHIP OR PLACE OF ORGANIZATION                 Delaware
-------------------------------------- -------- ----------------------------------------------------------------------

          NUMBER OF SHARES                7     SOLE VOTING POWER          -0-

        BENEFICIALLY OWNED BY             8     SHARED VOTING POWER        16,500,000

        EACH REPORTING PERSON             9     SOLE DISPOSITIVE POWER     -0-

                WITH                      10    SHARED DISPOSITIVE POWER   16,500,000
----------- ----------------------------------------------------------------------------------------------------------

    11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  16,500,000
----------- ------------------------------------------------------------------------------------------ ---------------

    12      CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
            (See Instructions)                                                  [ ]
----------- ----------------------------------------------------------------------------------------------------------

    13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)  22.7%
----------- ----------------------------------------------------------------------------------------------------------

    14      Type of Reporting Person (See Instructions)

                     PN
            ----------------------------------------------------------------------------------------------------------

            ----------------------------------------------------------------------------------------------------------

            ----------------------------------------------------------------------------------------------------------






*SEE INSTRUCTIONS BEFORE FILLING OUT.





-------------------------
CUSIP No.
-------------------------




         
=========== ==========================================================================================================

    1       NAMES OF REPORTING PERSONS
            Biomedical Offshore Value Fund, Ltd.
            I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON (ENTITIES ONLY):

            [            ]
----------- ----------------------------------------------------------------------------------------------------------

    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                                                       (a)  [ ]
                                                                                                       (b)  [ ]
----------- ----------------------------------------------------------------------------------------------------------

    3       SEC USE ONLY
----------- ----------------------------------------------------------------------------------------------------------

    4       Source of Funds (See Instructions)  PF
----------- ----------------------------------------------------------------------------------------------------------

    5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e)
----------- ----------------------------------------------------------------------------------------------------------

    6       CITIZENSHIP OR PLACE OF ORGANIZATION                 Cayman Islands
-------------------------------------- -------- ----------------------------------------------------------------------

          NUMBER OF SHARES                7     SOLE VOTING POWER          -0-

        BENEFICIALLY OWNED BY             8     SHARED VOTING POWER        13,500,000

        EACH REPORTING PERSON             9     SOLE DISPOSITIVE POWER     -0-

                WITH                      10    SHARED DISPOSITIVE POWER   13,500,000
----------- ----------------------------------------------------------------------------------------------------------

    11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  13,500,000
----------- ------------------------------------------------------------------------------------------ ---------------

    12      CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
            (See Instructions)                                                  [ ]
----------- ----------------------------------------------------------------------------------------------------------

    13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)  19.3%
---------- ----------------------------------------------------------------------------------------------------------

    14      Type of Reporting Person (See Instructions)

                     OO
            ----------------------------------------------------------------------------------------------------------

            ----------------------------------------------------------------------------------------------------------

            ----------------------------------------------------------------------------------------------------------
=========== ==========================================================================================================






*SEE INSTRUCTIONS BEFORE FILLING OUT.







-------------------------
CUSIP No.
-------------------------




         
=========== ==========================================================================================================

    1       NAMES OF REPORTING PERSONS
            Great Point Partners, LLC
            I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON (ENTITIES ONLY):

            [            ]
----------- ----------------------------------------------------------------------------------------------------------

    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                                                       (a)  [ ]
                                                                                                       (b)  [ ]
----------- ----------------------------------------------------------------------------------------------------------

    3       SEC USE ONLY
----------- ----------------------------------------------------------------------------------------------------------

    4       Source of Funds (See Instructions)  AF
----------- ----------------------------------------------------------------------------------------------------------

    5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e)
----------- ----------------------------------------------------------------------------------------------------------

    6       CITIZENSHIP OR PLACE OF ORGANIZATION                 Delaware
-------------------------------------- -------- ----------------------------------------------------------------------

          NUMBER OF SHARES                7     SOLE VOTING POWER          -0-

        BENEFICIALLY OWNED BY             8     SHARED VOTING POWER        30,000,000

        EACH REPORTING PERSON             9     SOLE DISPOSITIVE POWER     -0-

                WITH                      10    SHARED DISPOSITIVE POWER   30,000,000
----------- ----------------------------------------------------------------------------------------------------------

    11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  30,000,000
----------- ------------------------------------------------------------------------------------------ ---------------

    12      CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
            (See Instructions)                                                  [ ]
----------- ----------------------------------------------------------------------------------------------------------

    13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)  34.8%
---------- ----------------------------------------------------------------------------------------------------------

    14      Type of Reporting Person (See Instructions)

                     OO
            ----------------------------------------------------------------------------------------------------------

            ----------------------------------------------------------------------------------------------------------

            ----------------------------------------------------------------------------------------------------------
=========== ==========================================================================================================






*SEE INSTRUCTIONS BEFORE FILLING OUT.









-------------------------
CUSIP No.
-------------------------




         
=========== ==========================================================================================================

    1       NAMES OF REPORTING PERSONS
            Dr. Jeffrey R. Jay, M.D.
            I.R.S. IDENTIFICATION NOS. OF ABOVE PERSON (ENTITIES ONLY):

            [           ]
----------- ----------------------------------------------------------------------------------------------------------

    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                                                       (a)  [ ]
                                                                                                       (b)  [ ]
----------- ----------------------------------------------------------------------------------------------------------

    3       SEC USE ONLY
----------- ----------------------------------------------------------------------------------------------------------

    4       Source of Funds (See Instructions)  AF
----------- ----------------------------------------------------------------------------------------------------------

    5       Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e)
----------- ----------------------------------------------------------------------------------------------------------

    6       CITIZENSHIP OR PLACE OF ORGANIZATION                 Delaware
-------------------------------------- -------- ----------------------------------------------------------------------

          NUMBER OF SHARES                7     SOLE VOTING POWER          -0-

        BENEFICIALLY OWNED BY             8     SHARED VOTING POWER        30,000,000

        EACH REPORTING PERSON             9     SOLE DISPOSITIVE POWER     -0-

                WITH                      10    SHARED DISPOSITIVE POWER   30,000,000
----------- ----------------------------------------------------------------------------------------------------------

    11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON  30,000,000
----------- ------------------------------------------------------------------------------------------ ---------------

    12      CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
            (See Instructions)                                                  [ ]
----------- ----------------------------------------------------------------------------------------------------------

    13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)  34.8%
---------- ----------------------------------------------------------------------------------------------------------

    14      Type of Reporting Person (See Instructions)

                     IN
            ----------------------------------------------------------------------------------------------------------

            ----------------------------------------------------------------------------------------------------------

            ----------------------------------------------------------------------------------------------------------
=========== ==========================================================================================================






*SEE INSTRUCTIONS BEFORE FILLING OUT.




---------------------------
CUSIP No.
---------------------------



ITEM 1            SECURITY AND ISSUER:
                  --------------------

                  The  title  and  class of  equity  securities  to  which  this
statement relates is, Common Stock, par value $.001 per share.

                  The name and address of the principal executive offices of the
issuer is:

                  Neoprobe Corporation
                  425 Metro Place North
                  Suite 300
                  Dublin, Ohio 43017

ITEM 2            IDENTITY AND BACKGROUND:
                  ------------------------

                  The  identify  and  background  of  the  persons  filing  this
statement are as follows:

                  Biomedical  Value Fund,  L.P.  ("BMVF") is a Delaware  limited
partnership  with  its  principal  offices  at  2  Pickwick  Plaza,  Suite  450,
Greenwich, CT 06830.

                  Biomedical  Offshore Value Fund, Ltd.  ("BOVF") is an exempted
company  incorporated  under the  provisions  of the Companies Law of the Cayman
Islands with its principal office at P.O. Box 1748 GT, Cayman Corporate  Centre,
27 Hospital Road, Georgetown, Grand Cayman, Cayman Islands CJ08

                  Great Point Partners LLC ("Great Point") is a Delaware limited
liability  company,  with its principal offices at 2 Pickwick Plaza,  Suite 450,
Greenwich, CT 06830.

                  Dr.  Jeffrey  R.  Jay  ("Dr.  Jay")  is an  individual  with a
business address at 2 Pickwick Plaza, Suite 450, Greenwich, CT 06830. Dr. Jay is
a citizen of the United States.

                  None of the Reporting  Persons was during the last five years,
a party to a civil proceeding of a judicial or administrative  body of competent
jurisdiction and as a result of such proceeding was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, federal or state securities laws or finding any
violation with respect to such laws.

ITEM 3            SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION:
                  -------------------------------------------------

                  BMVF used its own funds to purchase an 8% Series A Convertible
Promissory Note of the issuer in the principal amount of $4,400,000 (convertible
into  11,000,000  shares of Common  Stock) and a Warrant  to  acquire  5,500,000
shares of Common  Stock.  BMVF  intends  to use its own  funds to  exercise  the
Warrant, to the extent it is exercised.

                  BOVF used its  funds to  purchase  an 8% Series A  Convertible
Promissory  Note  in  the  principal  amount  of  $3,600,000  (convertible  into
9,000,000  shares of Common Stock) and a Warrant to acquire  4,500,000 shares of
Common  Stock.  BOVF intends to use its funds to exercise  the  Warrant,  to the
extent it is exercised.





---------------------------
CUSIP No.
---------------------------


ITEM 4            PURPOSE OF TRANSACTION:
                  -----------------------

                  The purpose of the acquisition of the securities of the issuer
was for investment.

ITEM 5            INTEREST IN SECURITIES OF THE ISSUER:
                  ------------------------------------

                  BMVF owns in the aggregate  16,500,000  shares of Common Stock
of the issuer,  of which 11,000,000 shares are issuable upon conversion of an 8%
Series A Convertible Promissory Note in the principal amount of $4,400,000,  and
of which 5,500,000  shares are issuable upon exercise of a Warrant.  Such shares
in the  aggregate  constitute  22.7% of the shares of Common Stock  outstanding,
computed in accordance with Rule 13d-3.  BMVF share voting and dispositive power
over the shares of Common Stock that it beneficially owns.

                  BOVF owns in the aggregate  13,500,000  shares of Common Stock
of the issuer,  of which 9,000,000  shares are issuable upon conversion of an 8%
Series A Convertible Promissory Note in the principal amount of $3,600,000,  and
of which 4,500,000  shares are issuable upon exercise of a Warrant.  Such shares
in the  aggregate  constitute  19.3% of the shares of Common Stock  outstanding,
computed in accordance with Rule 13d-3.  BOVF share voting and dispositive power
over the shares of Common Stock that it beneficially owns.

                  Great Point is the investment manager of each of BMVF and BOVF
and by virtue of such  status  may be deemed to be the  beneficial  owner of the
shares of Common Stock held by BMVF and BOVF. Dr. Jay as senior  managing member
of Great Point has shared voting and investment power with respect to the shares
of Common  Stock  held by BMVF and BOVF and may be  deemed to be the  beneficial
owner of such shares.  Great Point and Dr. Jay disclaim beneficial  ownership of
the shares of Common  Stock  held by BMVF and BOVF,  except to the extent of any
pecuniary  interest,  and this statement  shall not be deemed to be an admission
that they are the beneficial owners of such securities.

ITEM 6            CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS  WITH
                  --------------------------------------------------------------
                  RESPECT TO  SECURITIES OF THE ISSUER:
                  -------------------------------------

                  BMVF and BOVF acquired the 8% Series A Convertible  Promissory
Notes and  Warrants of the issuer  pursuant to a Securities  Purchase  Agreement
dated as of December 13, 2004.  The Notes will bear interest at 8% per annum and
are freely  convertible  into shares of the issuer's  Common Stock at a price of
$.40 per  share.  The issuer may force  conversion  of the Notes  prior to their
stated maturity under certain  circumstances.  As part of the  transaction,  the
issuer issued  five-year  Warrants to BMVF and BOVF to purchase shares of Common
Stock at an exercise price of $.46. The issuer has agreed to file a registration
statement  with  the  Securities  and  Exchange  Commission  registering  shares
issuable upon conversion of the Notes and exercise of the Warrants no later than
30 days  following the closing.  The repayment of the Notes is secured by a lien
upon certain assets of the issuer pursuant to a Security Agreement.





---------------------------
CUSIP No.
---------------------------


ITEM 7            MATERIAL TO BE FILED AS EXHIBIT :
                  --------------------------------

                  The  following   documents  are  filed  as  exhibits  and  are
incorporated  by  reference  to the  issuer's  Form 8-K,  filed by the Issuer on
December 16, 2004;

EXHIBIT DESCRIPTION
-------------------

10.1   Securities  Purchase  Agreement,  dated as of December  13,  2004,  among
       Neoprobe  Corporation,  Biomedical Value Fund, L.P.,  Biomedical Offshore
       Value Fund, Ltd. and David C. Bupp. (Exhibit 10.1 to the Form 8-K)

10.2   Form of Neoprobe  Corporation  8% Series A Convertible  Promissory  Note.
       This is the Form of two substantially  identical notes issued to BMVF and
       BOVF. (Exhibit 10.2 to the Form 8-K)

10.3   Form of Neoprobe  Corporation  Purchase Warrant.  This is the Form of two
       substantially  identical warrants issued to BMVF and BOVF.  (Exhibit 10.3
       to the Form 8-K)

10.4   Security  Agreement  dated as of  December  13,  2004,  made by  Neoprobe
       Corporation in favor of Biomedical Value Fund, L.P.,  Biomedical Offshore
       Value Fund, ltd. and David C. Bupp. (Exhibit 10.5 to the Form 8-K)





















---------------------------
CUSIP No.
---------------------------


                                    SIGNATURE

                  After  reasonable  inquiry and to the best of my knowledge and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.

Date:  December 21, 2004



                                      Biomedical Value Fund, L.P.

                                      By:    Great Point GP, LLC,
                                             its general partner


                                      By:      /s/ DR. JEFFREY R. JAY
                                               ---------------------------------
                                               Name:  DR. JEFFREY R. JAY
                                                      --------------------------
                                               Its:  SENIOR MANAGING MEMBER
                                                     ---------------------------


                                      Biomedical Offshore Value Fund, Ltd.

                                      By:    Great Point Partners, LLC,
                                             its investment manager


                                      By:      /s/ DR. JEFFREY R. JAY
                                               ---------------------------------
                                               Name:  DR. JEFFREY R. JAY
                                                      --------------------------
                                               Its:  SENIOR MANAGING MEMBER
                                                     ---------------------------


                                      Great Point Partners, LLC

                                      By:      /s/ DR. JEFFREY R. JAY
                                               ---------------------------------
                                               Name:  DR. JEFFREY R. JAY
                                                      --------------------------
                                               Its:  SENIOR MANAGING MEMBER
                                                     ---------------------------

                                      /s/ DR. JEFFREY R. JAY
                                      ------------------------------------------
                                      Dr. Jeffrey R. Jay, individually






                                                                       EXHIBIT A


              AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE 13G

The undersigned hereby agree as follows:

         (i) Each of them is  individually  eligible to use the  Schedule 13D to
which this Exhibit is attached, and such Schedule 13D is filed on behalf of each
of them; and

         (ii) Each of them is responsible for the timely filing of such Schedule
13G and any amendments  thereto,  and for the  completeness  and accuracy of the
information  concerning  such  person  contained  therein;  but  none of them is
responsible for the  completeness or accuracy of the information  concerning the
other  persons  making the filing,  unless  such  person  knows or has reason to
believe that such information is inaccurate.

Date:  September 21, 2004

                                 Biomedical Value Fund, L.P.

                                 By:    Great Point GP, LLC,
                                        its general partner

                                 By:      /s/ DR. JEFFREY R. JAY
                                          --------------------------------------
                                          Name:  DR. JEFFREY R. JAY
                                                 -------------------------------
                                          Its:  SENIOR MANAGING MEMBER
                                                --------------------------------


                                 Biomedical Offshore Value Fund, Ltd.

                                 By:    Great Point Partners, LLC,
                                        its investment manager

                                 By:      /s/ DR. JEFFREY R. JAY
                                          --------------------------------------
                                          Name:  DR. JEFFREY R. JAY
                                                 -------------------------------
                                          Its:  SENIOR MANAGING MEMBER
                                                --------------------------------


                                 Great Point Partners, LLC

                                 By:      /s/ DR. JEFFREY R. JAY
                                          --------------------------------------
                                          Name:  DR. JEFFREY R. JAY
                                                 -------------------------------
                                          Its:  SENIOR MANAGING MEMBER
                                                --------------------------------

                                 /s/ DR. JEFFREY R. JAY
                                 -----------------------------------------------
                                 Dr. Jeffrey R. Jay, individually




                                 Great Point Partners, LLC


                                 By:  /s/ DR. JEFFREY R. JAY
                                      ------------------------------------------

                                 Name:    DR. JEFFREY R. JAY
                                          --------------------------------------
                                 Its:  SENIOR MANAGING MEMBER


                                 /s/ DR. JEFFREY R. JAY
                                 -----------------------------------------------
                                 Dr. Jeffrey R. Jay, individually