SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549
SCHEDULE 13G
(Rule 13d-102)
INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
TO RULES 13d-1(b) (c) AND (d) AND AMENDMENTS THERETO FILED
PURSUANT TO 13d-2(b)
(Amendment No. 3)*
Repligen Corporation (Name of Issuer) |
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Common Stock (Title of Class of Securities) |
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759916109 (CUSIP Number) |
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December 31, 2007 (Date of Event Which Requires Filing of this Statement) |
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
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| o Rule 13d-1(b) |
*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.
The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).
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CUSIP No. 759916109 |
| 13G |
| Page 2 of 10 Pages |
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1 |
| NAME OF REPORTING PERSON: |
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2 |
| CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* |
| (a) ý |
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| (b) o |
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3 |
| SEC USE ONLY |
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| CITIZENSHIP OR PLACE OF ORGANIZATION | ||
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Delaware |
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| 5 |
| SOLE VOTING POWER | ||||
NUMBER OF |
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| 0 | ||||
SHARES |
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BENEFICIALLY |
| 6 |
| SHARED VOTING POWER | ||||
OWNED |
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| 515,750 | ||||
BY |
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EACH |
| 7 |
| SOLE DISPOSITIVE POWER | ||||
REPORTING |
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| 0 | ||||
PERSON |
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WITH: |
| 8 |
| SHARED DISPOSITIVE POWER | ||||
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| 515,750 | ||||
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9 |
| AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
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515,750 |
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10 |
| CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* |
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11 |
| PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
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| 1.7% |
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| TYPE OF REPORTING PERSON* |
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PN |
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CUSIP No. 759916109 |
| 13G |
| Page 3 of 10 Pages |
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1 |
| NAME OF REPORTING PERSON: |
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2 |
| CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* |
| (a) ý |
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| (b) o |
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3 |
| SEC USE ONLY |
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| CITIZENSHIP OR PLACE OF ORGANIZATION |
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Delaware |
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| 5 |
| SOLE VOTING POWER | ||||
NUMBER OF |
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| 0 | ||||
SHARES |
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BENEFICIALLY |
| 6 |
| SHARED VOTING POWER | ||||
OWNED |
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| 325,400 | ||||
BY |
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EACH |
| 7 |
| SOLE DISPOSITIVE POWER | ||||
REPORTING |
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| 0 | ||||
PERSON |
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WITH: |
| 8 |
| SHARED DISPOSITIVE POWER | ||||
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| 325,400 | ||||
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9 |
| AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
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325,400 |
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10 |
| CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* |
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11 |
| PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
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| 1.1% |
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| TYPE OF REPORTING PERSON* |
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PN |
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CUSIP No. 759916109 |
| 13G |
| Page 4 of 10 Pages | ||||||||
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1 |
| NAME OF REPORTING PERSON: |
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2 |
| CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* |
| (a) ý | ||||||||
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3 |
| SEC USE ONLY |
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4 |
| CITIZENSHIP OR PLACE OF ORGANIZATION |
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| Delaware |
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| 5 |
| SOLE VOTING POWER | ||||||||
NUMBER OF |
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| 0 | ||||||||
SHARES |
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BENEFICIALLY |
| 6 |
| SHARED VOTING POWER | ||||||||
OWNED |
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| 1,116,700 | ||||||||
BY |
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EACH |
| 7 |
| SOLE DISPOSITIVE POWER | ||||||||
REPORTING |
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| 0 | ||||||||
PERSON |
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WITH: |
| 8 |
| SHARED DISPOSITIVE POWER | ||||||||
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| 1,116,700 | ||||||||
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9 |
| AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
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1,116,700 |
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10 |
| CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* |
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11 |
| PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
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| 3.6% |
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| TYPE OF REPORTING PERSON* |
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OO |
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CUSIP No. 759916109 |
| 13G |
| Page 5 of 10 Pages |
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1 |
| NAME OF REPORTING PERSON: |
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2 |
| CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* |
| (a) ý |
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| (b) o |
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3 |
| SEC USE ONLY |
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| CITIZENSHIP OR PLACE OF ORGANIZATION |
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Illinois | ||||
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| 5 |
| SOLE VOTING POWER | ||||
NUMBER OF |
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| 0 | ||||
SHARES |
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BENEFICIALLY |
| 6 |
| SHARED VOTING POWER | ||||
OWNED |
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| 123,100 | ||||
BY |
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EACH |
| 7 |
| SOLE DISPOSITIVE POWER | ||||
REPORTING |
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| 0 | ||||
PERSON |
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WITH: |
| 8 |
| SHARED DISPOSITIVE POWER | ||||
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| 123,100 | ||||
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9 |
| AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
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123,100 | |||||||
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10 |
| CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* |
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11 |
| PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
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| 0.4% |
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| TYPE OF REPORTING PERSON* |
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OO |
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CUSIP No. 759916109 |
| 13G |
| Page 6 of 10 Pages | ||||
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1 |
| NAME OF REPORTING PERSON: |
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2 |
| CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* |
| (a) ý | ||||
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| (b) o | ||||
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3 |
| SEC USE ONLY |
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4 |
| CITIZENSHIP OR PLACE OF ORGANIZATION |
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Delaware |
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| 5 |
| SOLE VOTING POWER | ||||
NUMBER OF |
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SHARES |
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BENEFICIALLY |
| 6 |
| SHARED VOTING POWER | ||||
OWNED |
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| 2,080,950 | ||||
BY |
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EACH |
| 7 |
| SOLE DISPOSITIVE POWER | ||||
REPORTING |
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PERSON |
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WITH: |
| 8 |
| SHARED DISPOSITIVE POWER | ||||
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| 2,080,950 | ||||
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9 |
| AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
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2,080,950 |
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10 |
| CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* |
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11 |
| PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
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| 6.7% |
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12 |
| TYPE OF REPORTING PERSON* |
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PN | ||||||||
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CUSIP No. 759916109 |
| 13G |
| Page 7 of 10 pages | |||||||||||
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1 |
| NAME OF REPORTING PERSON: |
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2 |
| CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* |
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3 |
| SEC USE ONLY |
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4 |
| CITIZENSHIP OR PLACE OF ORGANIZATION |
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Delaware |
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| SOLE VOTING POWER | |||||||||||
NUMBER OF |
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SHARES |
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BENEFICIALLY |
| 6 |
| SHARED VOTING POWER | |||||||||||
OWNED |
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| 2,080,950 | |||||||||||
BY |
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EACH |
| 7 |
| SOLE DISPOSITIVE POWER | |||||||||||
REPORTING |
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| 0 | |||||||||||
PERSON |
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WITH: |
| 8 |
| SHARED DISPOSITIVE POWER | |||||||||||
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| 2,080,950 | |||||||||||
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9 |
| AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
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2,080,950 |
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10 |
| CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* |
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11 |
| PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
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| 6.7% | ||||||||||||||
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12 |
| TYPE OF REPORTING PERSON* |
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| IA, CO |
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CUSIP No. 759916109 |
| 13G |
| Page 8 of 10 Pages |
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ITEM 1(a). NAME OF ISSUER:
Repligen Corporation (“Repligen”)
ITEM 1(b). ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:
41 Seyon Street
Building 1, Suite 100
Waltham, MA 02453
ITEM 2(a). NAME OF PERSON FILING:
This Amendment No. 3 to Schedule 13G is being filed on behalf of the following persons (the "Reporting Persons"):
| (i) |
| Biotechnology Value Fund, L.P. ("BVF") |
| (ii) |
| Biotechnology Value Fund II, L.P. ("BVF2") |
| (iii) |
| BVF Investments, L.L.C. ("Investments") |
| (iv) |
| Investment 10, L.L.C. ("ILL10") |
| (v) |
| BVF Partners L.P. ("Partners") |
| (vi) |
| BVF Inc. ("BVF Inc.") |
ITEM 2(b). ADDRESS OF PRINCIPAL BUSINESS OFFICE:
The principal business office of the Reporting Persons comprising the group filing this Amendment No. 3 to Schedule 13G is located at 900 North Michigan Avenue, Suite 1100, Chicago, Illinois, 60611.
ITEM 2(c). CITIZENSHIP:
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| BVF: | a Delaware limited partnership |
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| BVF2: | a Delaware limited partnership |
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| Investments: | a Delaware limited liability company |
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| ILL10: | an Illinois limited liability company |
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| Partners: | a Delaware limited partnership |
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| BVF Inc.: | a Delaware corporation |
ITEM 2(d). TITLE OF CLASS OF SECURITIES:
This Amendment No. 3 to Schedule 13G is being filed with respect to the common stock, par value $0.01 per share ("Common Stock"), of Repligen. The Reporting Persons' percentage ownership of Common Stock is based on 30,916,534 shares of Common Stock being outstanding.
As of December 31, 2007 BVF beneficially owned 515,750 shares of Common Stock, BVF2 beneficially owned 325,400 shares of Common Stock, Investments beneficially owned 1,116,700 shares of Common Stock and ILL10 beneficially owned 123,100 shares of Common Stock. Beneficial ownership by Partners and BVF Inc. includes 2,080,950 shares of Common Stock.
ITEM 2(e). CUSIP Number:
759916109
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CUSIP No. 759916109 |
| 13G |
| Page 9 of 10 Pages |
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ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(b), or 13d-2(b) or (c) CHECK WHETHER THE PERSON FILING IS: One of the following
Not applicable as this Amendment No. 3 to Schedule 13G is filed pursuant to Rule 13d-1(c).
ITEM 4. OWNERSHIP:
The information in items 1 and 5 through 11 on the cover pages (pp. 2 - 7) on this Amendment No. 3 to Schedule 13G is hereby incorporated by reference.
ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS:
If this statement is being filed to report the fact that as of the date hereof the Reporting Persons have ceased to be the beneficial owner of more than five percent of the class of securities check the following.
ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:
Pursuant to the operating agreement of Investments, Partners is authorized, among other things, to invest the funds of Ziff Asset Management, L.P., the majority member of Investments, in shares of the Common Stock beneficially owned by Investments and to vote and exercise dispositive power over those shares of the Common Stock. Partners and BVF Inc. share voting and dispositive power over shares of the Common Stock beneficially owned by BVF, BVF2, Investments and those owned by ILL10, on whose behalf Partners acts as an investment manager and, accordingly, Partners and BVF Inc. have beneficial ownership of all of the shares of the Common Stock owned by such parties.
ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY:
Not applicable.
ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF A GROUP:
Not applicable.
ITEM 9. NOTICE OF DISSOLUTION OF GROUP:
Not applicable.
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CUSIP No. 759916109 |
| 13G |
| Page 10 of 10 Pages |
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ITEM 10. CERTIFICATION
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
Dated: |
| February 1, 2008 |
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| Mark N. Lampert |
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| Mark N. Lampert |
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| Mark N. Lampert |
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| Mark N. Lampert |
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| /s/ Mark N. Lampert |
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| Mark N. Lampert |
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| Mark N. Lampert |