FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * Shacham Sharon   2. Issuer Name and Ticker or Trading Symbol Karyopharm Therapeutics Inc. [KPTI] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) President & CSO (Last) (First) (Middle) C/O KARYOPHARM THERAPEUTICS INC., 85 WELLS AVENUE 3. Date of Earliest Transaction (Month/Day/Year) 12/07/2017 (Street) NEWTON, MA 02459 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 12/07/2017   M(1)   10,000 A $ 0.264 723,510 (2) D   Common Stock 12/07/2017   S(1)   10,000 D $ 10.3903 (3) 713,510 D   Common Stock               512,143 (4) I By Spouse Common Stock               47,309 I By GRAT (5) Common Stock               47,309 I By Spouse's GRAT (6)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Stock Option (right to buy)

$ 0.264

12/07/2017

M(1)

10,000

(7)

12/13/2021

Common Stock

10,000

$ 0

29,394

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Shacham Sharon C/O KARYOPHARM THERAPEUTICS INC. 85 WELLS AVENUE NEWTON, MA 02459			President & CSO

Signatures

/s/Christopher B. Primiano, Attorney-in-Fact for Sharon Shacham		12/08/2017
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.
(2)	Reflects the contribution of 60,000 shares previously owned directly to the Sharon Shacham 2016 Qualified Annuity Interest Trust ("GRAT") on September 9, 2016 and the transfer of 12,691 shares from the GRAT to the reporting person on November 6, 2017.
(3)	Represents the weighted average sale price. These shares were sold in multiple transactions at prices ranging from $10.14 to $10.48, inclusive. The reporting person undertakes to provide upon request by the U.S. Securities and Exchange Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price.
(4)	Reflects the contribution of 60,000 shares previously owned directly by the spouse of the reporting person to the Michael G. Kauffman 2016 Qualified Annuity Interest Trust ("Spouse's GRAT") on September 9, 2016 and the transfer of 12,691 shares from the Spouse's GRAT to the spouse of the reporting person on November 6, 2017.
(5)	These shares are held by the GRAT.
(6)	These shares are held by the Spouse's GRAT.
(7)	This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on December 12, 2012, and the remaining 75% vested in 36 equal monthly installments thereafter.

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