Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
ADVANCED TECHNOLOGY VENTURES VII LP
  2. Issuer Name and Ticker or Trading Symbol
CRITICAL THERAPEUTICS INC [CRTX]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
1000 WINTER STREET, SUITE 3700
3. Date of Earliest Transaction (Month/Day/Year)
06/20/2005
(Street)

WALTHAM, MA 02451
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 06/20/2005   P   1,027,702 A $ 5.48 2,554,802 I By Advanced Technology Ventures VII, L.P. (1)
Common Stock 06/20/2005   P   41,241 A $ 5.48 102,522 I By Advanced Technology Ventures VII (B), L.P. (2)
Common Stock 06/20/2005   P   19,823 A $ 5.48 49,279 I By Advanced Technology Ventures VII (C), L.P. (3)
Common Stock 06/20/2005   P   6,125 A $ 5.48 15,225 I By ATV Entrepreneurs VII, L.P. (4)
Common Stock 06/20/2005   P   171,533 A $ 5.48 427,315 I By Advanced Technology Ventures VI, L.P. (5)
Common Stock 06/20/2005   P   10,949 A $ 5.48 27,275 I By ATV Entrepreneurs VI, L.P. (6)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Common Stock Warrant (right to buy) $ 6.58 06/20/2005   A   359,696   06/20/2005 06/20/2015 Common Stock 359,696 $ 0 359,696 I By Advanced Technology Ventures VII, L.P. (1)
Common Stock Warrant (right to buy) $ 6.58 06/20/2005   A   14,434   06/20/2005 06/20/2015 Common Stock 14,434 $ 0 14,434 I By Advanced Technology Ventures VII (B), L.P. (2)
Common Stock Warrant (right to buy) $ 6.58 06/20/2005   A   6,938   06/20/2005 06/20/2015 Common Stock 6,938 $ 0 6,938 I By Advanced Technology Ventures VII (C), L.P. (3)
Common Stock Warrant (right to buy) $ 6.58 06/20/2005   A   2,144   06/20/2005 06/20/2015 Common Stock 2,144 $ 0 2,144 I By ATV Entrepreneurs VII, L.P. (4)
Common Stock Warrant (right to buy) $ 6.58 06/20/2005   A   60,037   06/20/2005 06/20/2015 Common Stock 60,037 $ 0 60,037 I By Advanced Technology Ventures VI, L.P. (5)
Common Stock Warrant (right to buy) $ 6.58 06/20/2005   A   3,832   06/20/2005 06/20/2015 Common Stock 3,832 $ 0 3,832 I By ATV Entrepreneurs VI, L.P. (6)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
ADVANCED TECHNOLOGY VENTURES VII LP
1000 WINTER STREET
SUITE 3700
WALTHAM, MA 02451
    X    
Advanced Technology Ventures VII(B), L.P.
1000 WINTER STREET
SUITE 3700
WALTHAM, MA 02451
    X    
Advanced Technology Ventures VII(C), L.P.
1000 WINTER STREET
SUITE 3700
WALTHAM, MA 02451
    X    
ATV Entrepreneurs VII, L.P.
1000 WINTER STREET
SUITE 3700
WALTHAM, MA 02451
    X    
Advanced Technology Ventures VI, L.P.
1000 WINTER STREET
SUITE 3700
WALTHAM, MA 02451
    X    
ATV Entrepreneurs VI, L.P.
1000 WINTER STREET
SUITE 3700
WALTHAM, MA 02451
    X    
ATV Associates VII, L.L.C.
1000 WINTER STREET
SUITE 3700
WALTHAM, MA 02451
    X    
ATV Associates VI, L.L.C.
1000 WINTER STREET
SUITE 3700
WALTHAM, MA 02451
    X    

Signatures

 /s/ Jean M. George, Managing Director of ATV Associates VII, L.L.C.   06/22/2005
**Signature of Reporting Person Date

 /s/ Jean M. George, Managing Director of ATV Associates VII, L.L.C., which serves as the sole general partner of Advanced Technology Ventures VII, L.P.   06/22/2005
**Signature of Reporting Person Date

 /s/ Jean M. George, Managing Director of ATV Associates VII, L.L.C., which serves as the sole general partner of Advanced Technology Ventures VII (B), L.P.   06/22/2005
**Signature of Reporting Person Date

 /s/ Jean M. George, Managing Director of ATV Associates VII, L.L.C., which serves as the sole general partner of Advanced Technology Ventures VII (C), L.P.   06/22/2005
**Signature of Reporting Person Date

 /s/ Jean M. George, Managing Director of ATV Associates VII, L.L.C., which serves as the sole general partner of ATV Entrepreneurs VII, L.P.   06/22/2005
**Signature of Reporting Person Date

 /s/ Pieter J. Schiller, Managing Director of ATV Associates VI, L.L.C.   06/22/2005
**Signature of Reporting Person Date

 /s/ Pieter J. Schiller, Managing Director of ATV Associates VI, L.L.C., which serves as the sole general partner of Advanced Technology Ventures VI, L.P.   06/22/2005
**Signature of Reporting Person Date

 /s/ Pieter J. Schiller, Managing Director of ATV Associates VI, L.L.C., which serves as the sole general partner of ATV Entrepreneurs VI, L.P.   06/22/2005
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The shares are owned by Advanced Technology Ventures VII, L.P. ("ATV VII"), which is under common control with Advanced Technology Ventures VII (B), L.P. ("ATV VII(B)"), Advanced Technology Ventures VII (C), L.P. ("ATV VII(C)") and ATV Entrepreneurs VII, L.P. ("ATVE VII"). ATV Associates VII, L.L.C. serves as the sole general partner of ATV VII, ATV VII(B), ATV VII(C) and ATVE VII.
(2) The shares are owned by ATV VII(B).
(3) The shares are owned by ATV VII(C).
(4) The shares are owned by ATVE VII.
(5) The shares are owned by Advanced Technology Ventures VI, L.P. ("ATV VI"), which is under common control with ATV Entrepreneurs VI, L.P. ("ATVE VI"). ATV Associates VI, L.L.C. serves as the sole general partner of ATV VI and ATVE VI.
(6) The shares are owned by ATVE VI.

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