Filed Pursuant to Rule 424(b)(3)
File No. 333-134279

Prospectus Supplement No. 1
(To Prospectus dated May 31, 2006)

[GRAPHIC MISSING]

ZIOPHARM Oncology, Inc.

11,187,774 Shares

Common Stock



 

This prospectus supplement (this “Supplement”) supplements and amends the prospectus dated May 31, 2006 and included in our registration statement on Form S-3 (File No. 333-134279) filed on May 19, 2006 and declared effective by the U.S. Securities and Exchange Commission on May 30, 2006 (the “Prospectus”). The Prospectus initially related to the sale of up to 11,187,774 shares of our common stock by the selling shareholders named in the Prospectus or their donees, pledgees, transferees or other successors in interest, including 7,991,256 shares issued in a private placement transaction that we completed on May 3, 2006 (the “May 2006 Private Placement”) and 3,196,518 additional shares issuable upon the exercise of warrants that were issued in the May 2006 Private Placement. This Supplement does not relate to our issuance of additional shares of common stock beyond the 11,187,774 originally covered by the Prospectus.

This Supplement should be read in conjunction with, and may not be delivered or utilized without, the Prospectus, which is to be delivered with this Supplement. This Supplement is qualified by reference to the Prospectus, except to the extent that the information in this Supplement updates and supersedes the information contained in the Prospectus.

Our common stock trades on the NASDAQ Capital Market under the symbol “ZIOP.”

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if the Prospectus or this Supplement is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this prospectus supplement is March 4, 2011.


 
 

TABLE OF CONTENTS

SELLING STOCKHOLDERS

The information in the table appearing under the caption “Selling Shareholders” commencing on page 15 of the Prospectus is hereby superseded in its entirety by the information set forth in the table below. The information has been updated only to reflect assignments and other transfers of warrants to purchase our common stock that were initially acquired in the May 2006 Private Placement by the holders thereof.

The information set forth in the table below is current as of March 4, 2011. Since the date on which we were provided with the information regarding their security ownership in ZIOPHARM Oncology, Inc., selling stockholders may have acquired, sold, transferred or otherwise disposed of all or a portion of their securities. Accordingly, the information provided herein for any particular selling stockholder may understate or overstate, as the case may be, such stockholder’s current ownership.

       
Selling Stockholder   Shares
Beneficially
Owned Before
Offering(1)
  Number of
Outstanding Shares
Offered by Selling
Stockholder
  Number of Shares
Offering by Selling
Stockholder Upon
Exercise of
Certain Warrants
  Percentage
Beneficial
Ownership After
Offering(2)
ACM SPV LLC’s     2,119       0       2,119        
Alastair Muir-Taylor     7,019       5,399       1,620        
Albert M. Leftkovits, M.D.     7,019       5,399       1,620        
Albert Sebag     291       0       291        
Alfred J. Smith     7,019       5,399       1,620        
Amgis Capital International I LP     2,200       0       2,200        
Amgis Capital International I Ltd.     1,100       0       1,100        
Amita Rodman Mehta F/B/O ARM-TDA     467       0       467        
Amita Rodman Mehta IRA and IRA R/O     99       0       99        
AMP CAPITAL INVESTORS LIMITED AS RESPONSIBLE ENTITY FOR ENHANCED INDEX INTERNATIONAL SHARE FUND     37,516       0       37,516        
Andrew W. Albstein     14,039       10,799       3,240        
Andrew W. Schonzeit     8,423       6,479       1,944        
Andy Miles     74       0       74        
Anjali Doshi, minor, c/o Navin Doshi     69       0       69        
Anthony J. Ottavio     8,423       6,479       1,944        
Anthony Vitale     39,832       0       39,832        
Arthur Greco     7,019       5,399       1,620        
ARTUS GMBH & CO. KGaA(a)     70,194       53,995       16,199        
Barclays Bank (Suisse) S.A.     3,300       0       3,300        
Barry M. Pearl     7,615       4,319       1,296       *  
Basil Christakos     8,678       0       2,606       *  
BCMF Trustees, LLC     10,551       0       10,551        
Ben and Sophie Reuben     16,845       12,958       3,887        
Ben Heller     100,116       32,397       9,719       *  
Bernard S. Carrey     4,211       3,239       972        
Brenda M. Hackney     7,019       5,399       1,620        
Broadlawn Master Fund, Ltd.(b)     28,077       21,598       6,479        
Bruce W. Jaeger     45,401       34,924       10,477        
Bushido Capital Master Fund, LP(c)     71,284       64,794       6,490        
Carl Belczynski     54       0       54        
Carucci Family Partners(d)     81,155       32,397       9,719       *  
CFRR Holdings, LLC     161       0       161        

S-1


 
 

TABLE OF CONTENTS

       
Selling Stockholder   Shares
Beneficially
Owned Before
Offering(1)
  Number of
Outstanding Shares
Offered by Selling
Stockholder
  Number of Shares
Offering by Selling
Stockholder Upon
Exercise of
Certain Warrants
  Percentage
Beneficial
Ownership After
Offering(2)
Charles D. Kleinow     28,600       22,000       6,600        
Citigroup Global MKT Inc. as IRA Rollover Cust FBO Mai N. Pogue     14,300       11,000       3,300        
Clarion Capital Corporation(e)     98,271       75,593       22,678        
Common Fund Hedged Equity
Company(f)
    24,100       24,100       0        
Cooper A. McIntosh MD     11,231       8,639       2,592        
Cordillera Fund L.P.(g)     42,116       32,397       9,719        
Cranshire Capital, LP(h)     42,116       32,397       9,719        
Cycad Group, LLC(i)     140,390       107,992       32,398        
Daniel A. Bachtle     11,231       8,639       2,592        
David A. Dent     22,557       16,198       4,859       *  
David Jaroslawicz     69,616       32,397       9,719       *  
David S. Hannes     7,019       5,399       1,620        
DIVALVEST INC     3,502       0       3,502        
DKG Leasing-2000, LLC.     398       0       398        
Dr. G. Bruce Miles IRA R/O     2,807       2,159       648        
Drs. Maya and Mehul Shah     125       0       125        
Edmund Debler     3,012       0       3,012        
Edward and Sandra Meyer Foundation,
Inc.
    4,050       0       4,050        
Erich W. Wouters, M.D.     7,019       5,399       1,620        
Esther Stahler     28,077       21,598       6,479        
ETP/FBR Venture Capital II, LLC(j)     213,109       163,930       49,179        
Fernando Ahumada     11,231       8,639       2,592        
Finderne, LLC(k)     8,100       8,100       0        
FIRS Management, LLC(l)     11,231       8,639       2,592        
Fred Vitale     5,824       4,319       1,505        
Globe Capital Investors Biotech LLC(m)     143,477       110,367       33,110        
Good Steward Trading Company SPC     7,500       7,500       0        
Griffin Securities, Inc.     138,977       0       138,977        
Hackney One Investments, LLC(n)     7,019       5,399       1,620        
Harewood Nominees Ltd. A/C 4689000(o)     125,053       125,053       0        
Harewood Nominees Ltd. A/C 4721300(p)     42,116       32,397       9,719        
Harris Lydon     58,931       0       36,582       *  
Harry and Susan Newton JTWROS     38,591       16,198       4,859       *  
Hartwell Davis, Jr.     14,039       10,799       3,240        
Hauck & Aufhauser Banquiers Luxembourg S.A.(q)     22,461       17,278       5,183        
Henderson North American Multi-Strategy Equity Fund(r)     132,245       101,727       30,518        
Hollis Capital Partners, LP(s)     21,057       16,198       4,859        
Hollis N. Geiger, Jr.     7,019       5,399       1,620        
Investment Strategies Fund LP(t)     42,116       32,397       9,719        
Iroquois Master Fund Ltd.(u)     11,231       8,639       2,592        
J. Jay Lobell     94,252       26,997       8,099       *  

S-2


 
 

TABLE OF CONTENTS

       
Selling Stockholder   Shares
Beneficially
Owned Before
Offering(1)
  Number of
Outstanding Shares
Offered by Selling
Stockholder
  Number of Shares
Offering by Selling
Stockholder Upon
Exercise of
Certain Warrants
  Percentage
Beneficial
Ownership After
Offering(2)
J. Rainer Twiford     14,039       10,799       3,240        
Jacqueline P. Tanner     20,800       16,000       4,800        
James A. and Rosemarie Ingrassia JTWROS     19,655       15,119       4,536        
James B. Metzger     2,069       0       2,069        
James E. Cantrell, Jr.     14,039       10,799       3,240        
Jane R. Shoup IRA     7,019       5,399       1,620        
Jay Lobell     630       0       630        
Jeanne Marie Kiss IRA     467       0       467        
Jeff Eisenberg     7,019       5,399       1,620        
Jeffrey R. Johnson     5,615       4,319       1,296        
Jeffrey R. Marshall     18,323       0       18,323        
Jennifer & John McNealey     63       0       63        
Jimmie H. Harvey SEP IRA     5,399       5,399       0        
John Knox     19,470       0       10,362       *  
Jorge Ahumada     14,039       10,799       3,240        
Jorge Altschuler     11,231       8,639       2,592        
Joshua Moskowitz     42       0       42        
Julia R. Lucian     15,000       0       15,000        
Karl Ruggeberg     9,924       0       2,074       *  
Kazuaki Yonemoto     14,039       10,799       3,240        
Kenneth E. Bush, Jr.     7,019       5,399       1,620        
Kieran MacCarthy, minor, c/o Navin
Doshi
    69       0       69       *  
Klaus Kretschmer     28,077       21,598       6,479        
Knott Partners, L.P.(v)     200,900       200,900       0        
Lab Partners(w)     5,615       4,319       1,296        
Lakeside Partners LLC(x)     28,077       21,598       6,479        
Larry Gellman     70,194       53,995       16,199        
Laurie Widder Revocable Trust 2004     261       0       261        
LBI Group, Inc.(y)     1,123,109       863,930       259,179       *  
Les Fils Dreyfus & Cie S.A.     1,455       0       1,455        
Lewis Opportunity Fund, LP(z)     53,347       41,036       12,311        
Lindsay A. Rosenwald, M.D.(aa)     1,573,794       0       250,449       2.01 % 
Louis Smookler     17,326       0       5,181       *  
Mai N. and Gerald A. Pogue JTWROS     42,900       33,000       19,906       *  
Man Mash Limited     100                100        
Manali MacCarthy, minor, c/o Navin Doshi     69       0       69        
Mario Pasquel and Begona Miranda     23,254       5,399       1,620       *  
Mark Ahn     209       0       209        
Mark Zizzamia     44,956       0       44,956        
Mattherhorn Offshore Fund Limited     283,348       283,348       0           
Matthew A. King     7,019       5,399       1,620        
Michael A. Lindley     10,799       10,799       0        

S-3


 
 

TABLE OF CONTENTS

       
Selling Stockholder   Shares
Beneficially
Owned Before
Offering(1)
  Number of
Outstanding Shares
Offered by Selling
Stockholder
  Number of Shares
Offering by Selling
Stockholder Upon
Exercise of
Certain Warrants
  Percentage
Beneficial
Ownership After
Offering(2)
Michael G. Lindley and Nina Lindley Joint Tenants by the Entireties     3,240       0       3,240        
Michael Geschwer     104       0       104        
Michael Hoffman     1,283       0       1,283        
Michael Rosenman     64,797       0       32,943       *  
Michael Weiser(bb)     318,609       0       18,319       *  
Millennium Partners, L.P.(cc)     793,486       431,965       129,590       *  
Modern Capital Fund LLC(dd)     36,500       28,077       8,423        
Mosaix Ventures LP(ee)     210,583       161,987       48,596        
MP Asset Management LLC     19       0       19        
MP Asset Managers, L.P.     1,272       0       1,272        
MP BioPharmaceutical Partners, LP     17,710       17,710       0        
MP BioPharmaceutical Fund Ltd.     25,485       25,485       0        
Mr. Guy Pommares     36       0       36        
Murray J. McCabe     104,541       26,997       8,099       *  
N. Dean Meyer     28,600       22,000       6,600        
Natasha Doshi, minor, c/o Navin Doshi     69       0       69        
NBC Securities, Inc.     2,304       0       2,304        
Neal Polan     7,019       5,399       1,620        
Neil Herskowitz     25,805       5,399       1,620       *  
Neurosurgical Associates PC 401(k) Profit Sharing Trust FBO J. Finley McRae     5,399       5,399       0        
Nicholas B. Kronwall Trust
Dated 11/12/69(ff)
    11,231       8,639       2,592        
Nicole Berg     169,923       86,393       25,918       *  
Ocelot BioEquities Inc.     3,240       0       3,240        
Oppenheim Pramerica Asset Management S.a.r.l. on behalf of FCPOP Medical BioHealth-Trends(gg)     224,622       172,786       51,836        
Orest Bedrij     19,653       15,118       4,535        
OTA LLC(hh)     194,384       0       194,384           
Pam Investments LTD – I(ii)     28,600       22,000       6,600        
Pam Investments LTD – II(ii)     14,300       11,000       3,300        
Pamatlan, SA     821       0       821        
Panacea Capital L.P.(jj)     7,937       7,937       0        
Panacea Capital Offshore LTD(jj)     211,715       211,715       0        
Panacea Capital QP, LP(jj)     44,925       44,925       0        
Paul Boni     209       0       209        
Paul J. Solit     14,221       6,479       1,944       *  
Peter Barber     3,288       0       252       *  
Philip Isaacson     9,546       7,343       2,203        
Procific(kk)     1,320,004       1,079,914       323,974       *  
Procific(kk)     55,000       55,000       0        
ProQuest Investments III, L.P.(ll)     1,737,404       1,079,914       323,974       *  
Quantitative BioEquities (BVI) Fund, LTD(mm)     10,800       10,800       0        

S-4


 
 

TABLE OF CONTENTS

       
Selling Stockholder   Shares
Beneficially
Owned Before
Offering(1)
  Number of
Outstanding Shares
Offered by Selling
Stockholder
  Number of Shares
Offering by Selling
Stockholder Upon
Exercise of
Certain Warrants
  Percentage
Beneficial
Ownership After
Offering(2)
Ralph Rabman     117       0       117        
Reuben Taub     28,039       10,799       3,240       *  
Richard J. Kasten     7,559       7,559       0        
Richard J. Kasten 2005 Living Trust, Karen L. Kasten, Trustee     2,268       0       2,268        
Richard Maraviglia     470       0       470        
Riverside Contracting LLC(nn)     25,805       5,399       1,620       *  
Robert Friedman     777       0       777        
Rodney Cawood     7,019       5,399       1,620        
Roger Philipp     28,600       22,000       6,600        
Ropa Investments, Ltd     4,093       0       4,093        
Ruth Widder     209       0       209        
S.L. Goldblatt, Inc. Frozen Retirement Trust     615       0       615        
Salvatore Saraceno     44,956       0       44,956        
Sam J. Lewis     7,019       5,399       1,620        
Sanjan Dhody     8,423       6,479       1,944        
Scott G. Sink     7,019       5,399       1,620        
Scott Katzmann     65,760       0       36,943       *  
Sergio Masdival     7,019       5,399       1,620        
Shoshone Partners, L.P.(oo)     124,000       124,000       0        
Smithfield Fiduciary, LLC(pp)     512,708       215,982       64,795       *  
South Ferry #2, LP(qq)     140,388       107,991       32,397        
Stephen Rocamboli     51,039       0       10,362       *  
Sterling Securities Int. Ltd.(rr)     37,623       28,941       8,682        
Stern Agee & Leach Inc. C/F J. Finley McRae R/O IRA     1,620       0       1,620        
Stern Agee & Leach Inc. C/F William A. Legg, Jr. IRA     14,039       0       3,240       *  
Stern Agree & Leach Inc. C/F Jimmie H. Harvey Jr. SEP IRA     1,620       0       1,620        
Steve Lisi     2,156       0       2,156        
Steven Tish     107       0       107        
Stuart Gollomp     5,138       3,952       1,186        
Susan Rho     14,300       11,000       3,300        
Sushant Kumar     68       0       68        
Suzanne Brandt     7,019       5,399       1,620        
Tanna Enterprises, LLC(ss)     7,019       5,399       1,620        
The Weyers Group, LLC(tt)     14,039       10,799       3,240        
Thomas A. Lambert, III     7,019       5,399       1,620        
Thomas J. Curtin, Sr.     14,039       10,799       3,240        
Timothy McInerney(uu)     626,923       0       80,737       *  
Tokenhouse Trading Pte Ltd(vv)     74,463       21,598       6,479       *  
Tony Nikolich     8,423       6,479       1,944        
Vanac Industries, Inc.     89       0       89        
Vidacos Nominees Designation Misefl     52,295       0       52,295        

S-5


 
 

TABLE OF CONTENTS

       
Selling Stockholder   Shares
Beneficially
Owned Before
Offering(1)
  Number of
Outstanding Shares
Offered by Selling
Stockholder
  Number of Shares
Offering by Selling
Stockholder Upon
Exercise of
Certain Warrants
  Percentage
Beneficial
Ownership After
Offering(2)
Viram Foundation     1,271       0       1,271        
Viram Foundation     1,069       0       1,069        
Viren Mehta and Amita Rodman Mehta     1,582       0       1,582        
Viren Mehta IRA and R/O IRA     770       0       770        
Visium Balanced Fund, LP(ww)     241,409       185,699       55,710        
Visium Balanced Offshore Fund, LTD(ww)     360,792       277,532       83,260        
Visium Long Bias Fund, LP(ww)     72,593       55,841       16,752        
Visium Long Bias Offshore Fund, LTD(ww)     243,348       187,191       56,157        
W. Charles Mayer III     7,019       5,399       1,620        
W.S. Investments, L.P.     6,027       0       6,027        
Wiley H. Cooper IV     7,019       5,399       1,620        
William A. Legg, Jr.     10,799       10,799       0        
William Odenthal     7,000       0       7,000        
Total           7,991,256       3,196,518        

(1) Beneficial ownership is determined in accordance with SEC rules, beneficial ownership includes any shares as to which the security or stockholder has sole or shared voting power or investment power, and also any shares which the security or stockholder has the right to acquire within 60 days of the date hereof, whether through the exercise or conversion of any stock option, convertible security, warrant or other right. The indication herein that shares are beneficially owned is not an admission on the part of the security or stockholder that he, she or it is a direct or indirect beneficial owner of those shares.
(2) Assumes sales of all shares by the selling stockholders.
(a) Bernd Fortson has voting and investment control over the shares held by the selling stockholder.
(b) Jon Bloom, Managing Partner of the selling stockholder, has voting and investment control over the shares held by the selling stockholder.
(c) Christopher Rossman, Managing Partner of Bushido Capital Partners, Ltd., a Cayman Islands company and the General Partner of the selling stockholder, has voting and investment control over the shares held by the selling stockholder.
(d) Walter Carucci has voting and investment control over the shares held by the selling stockholder.
(e) Morton A. Cohen has voting and investment control over the shares held by the selling stockholder.
(f) David M. Knott has voting and investment control over the shares held by the selling stockholder.
(g) James P. Andrew and Stephen J. Carter share voting and investment control over the shares held by the selling stockholder.
(h) Mitchell P. Kopin, President of Downsview Capital, the General Partner of the selling stockholder, has voting and investment control over the shares held by the selling stockholder.
(i) K. Leonard Judson and Paul F. Glenn share voting and investment control over the shares held by the selling stockholder.
(j) Wei-Wu He and Bill Snider share voting and investment control over the shares held by the selling stockholder.
(k) David M. Knott has voting and investment control over the shares held by the selling stockholder.
(l) John B. Dimmer and John C. Dimmer share voting and investment control over the shares held by the selling stockholder.
(m) Larry Kopp has voting and investment control over the shares held by the selling stockholder.
(n) Brenda M. Hackney has voting and investment control over the shares held by the selling stockholder.
(o) Robert Villiers has voting and investment control over the shares held by the selling stockholder.
(p) Robert Villiers has voting and investment control over the shares held by the selling stockholder.

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(q) Jungbluth Fredy has voting and investment control over the shares held by the selling stockholder.
(r) Robert Villiers has voting and investment control over the shares held by the selling stockholder.
(s) Paul Siegel and Sheri Siegel share voting and investment control over the shares held by the selling stockholder.
(t) Matthew Shefler has voting and investment control over the shares held by the selling stockholder.
(u) Joshua Silverman has voting and investment control over the shares held by the selling stockholder. Mr. Silverman disclaims beneficial ownership of such shares.
(v) David M. Knott has voting and investment control over the shares held by the selling stockholder.
(w) Lillian Hahn and Barry J. Hahn share voting and investment control over the shares held by the selling stockholder.
(x) Jamie Stahler has voting and investment control over the shares held by the selling stockholder.
(y) Jeff Ferrell and Henry Klein share voting and investment control over the shares held by the selling stockholder.
(z) W. Austin Lewis IV has voting and investment control over the shares held by the selling stockholder.
(aa) Includes 563,296 shares that the selling stockholder has the right to acquire from existing stockholders under certain circumstances pursuant to the terms of pledge agreements between the selling stockholder and such existing stockholders.
(bb) Dr. Weiser is a director of the Company.
(cc) Millennium Management, L.L.C., a Delaware limited liability company, is the managing partner of Millennium Partners, L.P., a Cayman Islands exempted limited partnership, and consequently may be deemed to have voting control and investment discretion over securities owned by Millennium Partner, L.P. Israel A. Englander is the managing member of Millennium Management, L.L.C. As a result, Mr. Englander may be deemed to be the beneficial owner of any shares deemed to be beneficially owned by Millennium Management, L.L.C. The foregoing should not be construed in and of itself as an admission by either of Millennium Management, l.L.C. or Mr. Englander as to the beneficial ownership of the shares held by Millennium Partners, L.P.
(dd) Dennis Mykytyn has voting and investment control over the shares held by the selling stockholder.
(ee) Ranjan Lal has voting and investment control over the shares held by the selling stockholder.
(ff) Nicholas B. Kronwall, as trustee of the selling stockholder, has voting and investment control over the shares held by the selling stockholder.
(gg) Dr. Bernd Borgmeier, Dr. Rupert Hengster, J. Gabriel Irwin, Ferdinand-Alexander Leisten, Stephen Pelletier, Susan M. Scheader, John P. Smalling, Andreas Jockel, Harry Rosenbaum, Ute Becker, Alexander Schullgen, Max vo Frantzius, Peter Balle, Thomas Becker, Julia Brauckman, Otmar Gorges, Detlef Vallender, Johann Will, Andreas Becker, Katja Kirchen, Ralf Klein and Ulrike Sauer share voting and investment control over the shares held by the selling stockholder.
(hh) Ira Levanthal, as senior managing director, has voting and investment control over the shares held by the selling stockholder.
(ii) Mai N. Pogue, as investment manager, has voting and investment control over the shares held by the selling stockholder.
(jj) Edmund Debler and Steve Lisi has voting and investment control over the shares held by the selling stockholder.
(kk) Hamza Amiri and Abubaker Khouri share voting and investment control over the shares held by the selling stockholder.
(ll) Jay Moorin and Alain Schreiber share voting and investment control over the shares held by the selling stockholder.
(mm) Mikael Van Loon and Pete Levin share voting and investment control over the shares held by the selling stockholder.
(nn) Neil Herskowitz and Elliot Herskowitz share voting and investment control over the shares held by the selling stockholder.
(oo) David M. Knott has voting and investment control over the shares held by the selling stockholder.
(pp) Highbridge Capital Management, LLC is the trading manager of Smithfield Fiduciary, LLC and has voting control and investment decision over securities held by Smithfield Fiduciary, LLC. Glenn Dubin

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and Henry Swieca control Highbridge Capital Management, LLC. Each of Highbridge Capital Management, LLC, Glen Dubin and Henry Swieca disclaim beneficial ownership of the securities held by Smithfield Fiduciary, LLC.
(qq) Morris Wolfson has voting and investment control over the shares held by the selling stockholder.
(rr) Chris Bonvini has voting and investment control over the shares held by the selling stockholder.
(ss) Donna Darty has voting and investment control over the shares held by the selling stockholder.
(tt) Robert J. Weyers and Jeffrey J. Weyers share voting and investment control over the shares held by the selling stockholder.
(uu) Mr. McInerney is a director of the Company.
(vv) Christina Berger, Gordana Djurin, Andrea Delgado and Christina Bellman share voting and investment control over the shares held by the selling stockholder.
(ww) Jacob Gottlieb and Dmitry Balyasny share voting and investment control over the shares held by the selling stockholder.

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