Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
FRATES JAMES M
   2. Issuer Name and Ticker or Trading Symbol
Alkermes plc. [ALKS] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
SVP, Alks Inc; CFO ALKS
(Last)
(First)
(Middle)
CONNAUGHT HOUSE, 1 BURLINGTON ROAD		 3. Date of Earliest Transaction (Month/Day/Year)
12/07/2016
(Street)

DUBLIN 4 Ireland		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Ordinary Shares 12/07/2016   M(1)   13,731 A $ 15.95 126,073 (2) D  
Ordinary Shares 12/07/2016   M(1)   10,000 A $ 11.74 136,073 D  
Ordinary Shares 12/07/2016   S(3)   5,496 D $ 55.6454 (4) 130,577 D  
Ordinary Shares 12/07/2016   S(3)   17,379 D $ 56.4375 (5) 113,198 D  
Ordinary Shares 12/07/2016   S(3)   856 D $ 57.2167 (6) 112,342 D  
Ordinary Shares               4,000 I By Sons
Ordinary Shares               41,041 I By 2014 GRAT (7)
Ordinary Shares               16,562 I By 2015 GRAT (8)
Ordinary Shares               11,421 I By 2015 GRAT No. 2 (9)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Non Qualified Stock Option (Right to Buy) $ 15.95 12/07/2016   M(1)     13,731   (10) 06/01/2017 Ordinary Shares 13,731 $ 0 0 D  
Employee Stock Option (Right to Buy) $ 11.74 12/07/2016   M(1)     10,000   (10) 05/17/2020 Ordinary Shares 10,000 $ 0 51,983 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
FRATES JAMES M
CONNAUGHT HOUSE
1 BURLINGTON ROAD
DUBLIN 4 Ireland		       SVP, Alks Inc; CFO ALKS  

Signatures

 /s/ Jennifer Baptiste, attorney-in-fact for James M. Frates   12/08/2016
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.
(2) Includes 18,579 shares received on December 5, 2016 pursuant to an annuity payment from the James M. Frates Grantor Retained Annuity Trust No. 2 dated November 25, 2015 (the "2015 GRAT No. 2") which was exempt from reporting obligations by virtue of Rule 16a-13 promulgated under the Securities Exchange Act of 1934, as amended.
(3) This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.
(4) The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $55.09 to $56.08. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
(5) The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $56.10 to $57.06. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
(6) The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $57.14 to $57.33. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
(7) Shares held by James M. Frates Grantor Retained Annuity Trust dated March 14, 2014 (the "GRAT"). The Reporting Person is a trustee and beneficiary of the GRAT and may be deemed to hold voting and dispositive power with regard to the reported shares held by the GRAT.
(8) Shares held by the James M. Frates Grantor Retained Annuity Trust dated May 29, 2015 (the "2015 GRAT"). The Reporting Person is a trustee and beneficiary of the 2015 GRAT and may be deemed to hold voting and dispositive power with regard to the reported shares held by the 2015 GRAT.
(9) Shares held by the James M. Frates Grantor Retained Annuity Trust No. 2 dated November 25, 2015 (the "2015 GRAT No. 2"). The Reporting Person is a trustee and beneficiary of the 2015 GRAT No. 2 and may be deemed to hold voting and dispositive power with regard to the reported shares held by the 2015 GRAT No. 2.
(10) These options are fully vested in accordance with their terms.

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