OMB APPROVAL OMB Number:3235-0145 Expires: August 31, 1999 Estimated average burden hours per response 14.90 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1) Durect Corp. (Name of Issuer) Common Shares (Title of Class of Securities) 266605104 (CUSIP Number) December 31, 2003 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: /_X_/ Rule 13d-1(b) * The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page. The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 1745 (3-98) Page 1 of 11 CUSIP No. 266605104 13G Page 2 of 11 ---------------------------------------------------------------- 1 NAME OF REPORTING PERSONS IRS IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) RS Investment Management Co. LLC ---------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a)/ / (b)/ / ---------------------------------------------------------------- 3 SEC USE ONLY ---------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware ---------------------------------------------------------------- NUMBER OF 5 SOLE VOTING POWER SHARES -0- BENEFICIALLY --------------------------------------- OWNED BY 6 SHARED VOTING POWER EACH -5,836,200- REPORTING --------------------------------------- PERSON 7 SOLE DISPOSITIVE POWER WITH -0- --------------------------------------- 8 SHARED DISPOSITIVE POWER -5,836,200- ---------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON -5,836,200- ---------------------------------------------------------------- 10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) ---------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 11.4% ---------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (See Instructions) OO, HC ---------------------------------------------------------------- CUSIP No. 266605104 13G Page 3 of 11 ---------------------------------------------------------------- 1 NAME OF REPORTING PERSONS IRS IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) RS Investment Management, L.P. ---------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a)/ / (b)/ / ---------------------------------------------------------------- 3 SEC USE ONLY ---------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION California ---------------------------------------------------------------- NUMBER OF 5 SOLE VOTING POWER SHARES -0- BENEFICIALLY --------------------------------------- OWNED BY 6 SHARED VOTING POWER EACH -5,821,400- REPORTING --------------------------------------- PERSON 7 SOLE DISPOSITIVE POWER WITH -0- --------------------------------------- 8 SHARED DISPOSITIVE POWER -5,821,400- ---------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON -5,821,400- ---------------------------------------------------------------- 10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) ---------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 11.4% ---------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (See Instructions) PN, IA ---------------------------------------------------------------- CUSIP No. 266605104 13G Page 4 of 11 ---------------------------------------------------------------- 1 NAME OF REPORTING PERSONS IRS IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) G. Randall Hecht ---------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a)/ / (b)/ / ---------------------------------------------------------------- 3 SEC USE ONLY ---------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware ---------------------------------------------------------------- NUMBER OF 5 SOLE VOTING POWER SHARES -0- BENEFICIALLY --------------------------------------- OWNED BY 6 SHARED VOTING POWER EACH -5,836,200- REPORTING --------------------------------------- PERSON 7 SOLE DISPOSITIVE POWER WITH -0- --------------------------------------- 8 SHARED DISPOSITIVE POWER -5,836,200- ---------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON -5,836,200- ---------------------------------------------------------------- 10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) ---------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 11.4% ---------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (See Instructions) HC, IN ---------------------------------------------------------------- CUSIP No. 266605104 13G Page 5 of 11 ---------------------------------------------------------------- 1 NAME OF REPORTING PERSONS IRS IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) RS Diversified Growth Fund ---------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a)/ / (b)/ / ---------------------------------------------------------------- 3 SEC USE ONLY ---------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Massachusetts ---------------------------------------------------------------- NUMBER OF 5 SOLE VOTING POWER SHARES -0- BENEFICIALLY --------------------------------------- OWNED BY 6 SHARED VOTING POWER EACH -2,868,400- REPORTING --------------------------------------- PERSON 7 SOLE DISPOSITIVE POWER WITH -0- --------------------------------------- 8 SHARED DISPOSITIVE POWER -2,868,400- ---------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON -2,868,400- ---------------------------------------------------------------- 10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) ---------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 5.6% ---------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (See Instructions) IV ----------------------------------------------------------------- CUSIP No. 266605104 13G Page 6 of 11 ITEM 1. (a) The name of the issuer is Durect Corp. (the "Issuer"). (b) The principal executive office of the Issuer is located at: 10240 Bubb Road, Cupertino, CA 95014. ITEM 2. (a-c) See Annex I for information on the persons filing this statement (collectively, the "Filers") (d) This statement relates to shares of common stock of the Issuer (the "Stock"). (e) The CUSIP number of the Stock is 266605104. CUSIP No. 266605104 13G Page 7 of 11 ITEM 3. If this statement is filed pursuant to rule 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a: (a) ___ Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o). (b) ___ Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c). (c) ___ Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c). (d) _X*_ Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8). *RS Diversified Growth Fund is a registered investment company. (e) _X*_ An investment adviser in accordance with 240.13d- 1(b)(1)(ii)(E). *RS Investment Management, L.P. is a registered investment adviser. (f) ___ An employee benefit plan or endowment fund in accordance with 240.13d-1(b)(1)(ii)(F). (g) _X*_ A parent holding company or control person in accordance with 240.13d-1(b)(1)(ii)(G). *RS Investment Management Co. LLC is the general partner of RS Investment Management, L.P. G. Randall Hecht is a control person of RS Investment Management Co. LLC and RS Investment Management, L.P. (h) ___ A savings association as defined in section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813). (i) ___ A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3). (j) ___ Group, in accordance with section 240.13d-1(b)(1)(ii)(J) CUSIP No. 266605104 13G Page 8 of 11 ITEM 4. OWNERSHIP See Items 5-9 and 11 on the cover page for each Filer. ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following /___/. ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON RS Investment Management Co. LLC is the parent company of registered investment advisers whose clients have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the Stock. No individual client's holdings of the Stock, except for the RS Diversified Growth Fund, are more than five percent of the outstanding Stock. RS Investment Management, L.P. is a registered investment adviser and the investment adviser to RS Diversified Growth Fund, a registered investment company. RS Investment Management Co. LLC is the General Partner of RS Investment Management, L.P. G. Randall Hecht is a control person of RS Investment Management Co. LLC and RS Investment Management, L.P. CUSIP No. 266605104 13G Page 9 of 11 ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY Not applicable. ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP Not applicable. ITEM 9. NOTICE OF DISSOLUTION OF GROUP Not applicable. ITEM 10. CERTIFICATION By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. SIGNATURE After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Dated: February 14, 2004 RS INVESTMENT MANAGEMENT CO. LLC By: /s/ G. Randall Hecht G. Randall Hecht Chief Executive Officer RS INVESTMENT MANAGEMENT, L.P. By: /s/ G. Randall Hecht G. Randall Hecht Chief Executive Officer RS DIVERSIFIED GROWTH FUND By: RS INVESTMENT MANAGEMENT, L.P. Investment Adviser By: /s/ G. Randall Hecht G. Randall Hecht Chief Executive Officer /s/ G. Randall Hecht G. Randall Hecht CUSIP No. 266605104 13G Page 10 of 11 EXHIBIT A JOINT FILING AGREEMENT The undersigned hereby agree that they are filing this statement jointly pursuant to Rule 13d-1(f)(1). Each of them is responsible for the timely filing of the Schedule 13G and any amendments thereto, and for the completeness and accuracy of the information concerning such person contained therein; but none of them is responsible for the completeness or accuracy of the information concerning the other persons making the filing, unless such person knows or has reason to believe that such information is accurate. Dated: February 14, 2004 RS INVESTMENT MANAGEMENT CO. LLC By: /s/ G. Randall Hecht G. Randall Hecht Chief Executive Officer RS INVESTMENT MANAGEMENT, L.P. By: /s/ G. Randall Hecht G. Randall Hecht Chief Executive Officer RS DIVERSIFIED GROWTH FUND By: RS INVESTMENT MANAGEMENT, L.P. Investment Adviser By: /s/ G. Randall Hecht G. Randall Hecht Chief Executive Officer /s/ G. Randall Hecht G. Randall Hecht CUSIP No. 266605104 13G Page 11 of 11 Annex I The filers are: I. (a) RS Investment Management Co. LLC, is a Delaware Limited Liability Company. (b) holding company II. (a) RS Investment Management, L.P. is a California Limited Partnership (b) registered investment adviser III. (a) RS Diversified Growth Fund is a series of a Mass. Business Trust. (b) investment company IV. (a) G. Randall Hecht is a control person of RS Investment Management Co. LLC and RS Investment Management, L.P. (b) individual